Statistical Design of Pools Using Optimal Coverage and Minimal Collision

Discovery of a new drug involves screening large chemical libraries to identify active compounds. Screening efficiency can be improved by testing compounds in pools. We consider two criteria to design pools: optimal coverage of the chemical space and minimal collision between compounds. Five pooling designs are applied to a public data set. We evaluate each method by determining how well the de...

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Statistical Design of Pools Using Optimal Coverage and Minimal Collision -- Institutue of Statistics Mimeo Series 2549

Discovery of a new drug involves screening large chemical libraries to identify active compounds. Screening efficiency can be improved by testing compounds in pools. We consider two criteria to design pools: optimal coverage of the chemical space and minimal collision between compounds. Five pooling designs are applied to a public data set. We evaluate each method by determining how well the de...

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the study of practical and theoretical foundation of credit risk and its coverage

پس از بررسی هر کدام از فاکتورهای نوع صنعت, نوع ضمانت نامه, نرخ بهره , نرخ تورم, ریسک اعتباری کشورها, کارمزد, ریکاوری, gdp, پوشش و وثیقه بر ریسک اعتباری صندوق ضمانت صادرات ایران مشخص گردید که همه فاکتورها به استثنای ریسک اعتباری کشورها و کارمزد بقیه فاکتورها رابطه معناداری با ریسک اعتباری دارند در ضمن نرخ بهره , نرخ تورم, ریکاوری, و نوع صنعت و ریسک کشورها اثر عکس روی ریسک اعتباری داردو پوشش, وثی...

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Formulation and Optimization of Captopril Sublingual Tablet Using D-Optimal Design Sublingual Tablet Using D-Optimal Design

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

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Formulation and Optimization of Captopril Sublingual Tablet Using D-Optimal Design Sublingual Tablet Using D-Optimal Design

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

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Statistical Design of Pools Using Optimal Coverage and Minimal Collision

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